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Monday, March 4, 2013

Find out everything you need to know about shock: definition, types, pathogenesis, morphological changes in the body, clinical features, stages and treatment of cardiogenic, hypovolaemic and septic shock...

What is SHOCK?

Shock is a disorder that result from systemic hypo-perfusion due to reduction either in cardiac output or in the effective circulating blood volume.
Common Causes of shock are profuse haemorrhage, large myocardial infarction, severe diarrhoea, severe vomiting, extensive burn, trauma, bacterial sepsis, and pulmonary embolism.

Effects of Hypo-perfusion:

Due to hypo-perfusion there is less supply (hypoxia) of oxygen and nutrients to the cells and tissues and inadequate removal of metabolites. 
Hypoxia leads to less aerobic and more anaerobic metabolism with increased production of lactic acid. At first there is reversible injury to cells which passes on to irreversible injury with persistence or severe shock (see stages of shock below). Finally there may be necrosis of cells or even death of the patient.