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Saturday, February 23, 2013

Hepatitis A virus: (infectious hepatitis):
Structure of Hepatitis A virus


1.    It is a member of picorna group of enterovirus

2.    Single stranded RNA virus with one serotype

3.    Non-enveloped, Icosahedral nucleocapsid

4.    Replicate in the cytoplasm, inactivated by heat

5.    HAV is highly infectious and spread by the faeco-oral route

Some facts about Hepatitis A virus

NOTE: Infected individuals also may be asymptomatic, excrete the virus in faeces for about 2-3 weeks before the onset of symptoms and then for a further 2 weeks or so.

Viral hepatitis is a common cause of jaundice and must be considered in anyone presenting with hepatitis blood test (high aminotransaminase).

All hepatitis virus cause illness and similar clinical and pathological features and are frequently an-icteric or even asymptomatic.

They differ in their tendency to cause acute and chronic infection.

Classification of hepatitis virus:

A. Hepatotrophic / Classical virus:

Five commonly medically important virus are described as hepatotrophic virus as their main site of infection is liver. They are:

Structure of Hepatitis B virus
2.    Hepatitis B virus
3.    Hepatitis C virus
4.    Hepatitis D virus
5.    Hepatitis E virus
6.    Hepatitis G virus

B. Other viruses responsible for hepatitis:

1.    Epstein-Barr virus
2.    Cytomegalo virus
3.    Yellow fever virus
4.    Herpes virus
5.    Rubella virus
6.    Adeno virus