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Tuesday, October 4, 2011

Aplastic anaemia: What is it? Classification & Causes, Drug Idiosyncracy

Aplastic anaemia

A disorder of unknown aetiology characterized by anaemia, leucopenia and thrombocytopenia resulting from aplasia of the bone marrow.

In reality aplasia of the bone marrow is absent and hypoplasia occurs.

Classification of aplastic anaemia:

1. Primary or Idiopathic: No cause is known

2. Secondary:

                a. Drug idiosyncracy

                                -Cytotoxic drugs-most common
                                -Antibacterial drugs
                                -Antirheumatic drugs
                                -Antidiabetic drugs
                                -Anticonvulsant drugs

                b. Chemical exposure:

                                -Hair dye

               c. Viral hepatitis
                d. Ionizing radiation

                                -Diagnostic radiotherapy
                                -Industrial radiography

                e. Pure red cell aplasia

3. Constitutional –associated with inherited defects in DNA repair eg Fanconi’s syndrome.

What is drug idiosyncracy?

Abnormal reaction to a drug which cause various clinical manifestations.

Reference : In the making of the above article the follwing books were used:

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