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Thursday, February 21, 2013

Rota Virus: Properties, Disease, Clinical Features, Pathogenesis, Lab Diagnosis


Rota virus

Properties of rota virus:

1.   Family - retrovirus
2.   Non-enveloped, RNA virus
3.   Double stranded, Segmented virus
4.   It is surrounded by a double-layered Icosahedral capsid without an envelop
5.   2 major sub-group, 6 serotypes of human rotavirus
6.   Transmission by faeco-oral route
7.   The outer surface protein is type specific Ag( viral haemagglutinin)

Disease caused by rota virus:

Gastro-enteritis in infants and children. Rota virus cause non-bloody, non-invasive, watery diarrhea in infants and young children (2-6 years)

Clinical Features of Rota Virus Disease


Pathogenesis of Rota Virus:

Incubatino Period: 1-5 days
1.   Transmission by faeco-oral route
2.   Goes with the SI mucosa and bind with Rc
3.   Replicate in the cell cytoplasm
4.   Lysis of host cell as a result of virus injection within the mucosal cell, some cytokines are released and these cytokines stimulate neurons of SI
5.   Mucosal cell release fluid, electrolytes, sugar, AA
6.   Production of watery diarrhea
N.B.: Rotavirus diarrhea may be lethal to the children due to dehydration and electrolyte imbalance

Lab Diagnosis of Rota Virus:
1.   By detecting the Rota virus in stool - ELISA, RIA, Electron microscopy
2.   By detecting 4 fold rise of Ab titer in patient serum

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