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Tuesday, October 4, 2011

Pernicious anaemia: What is it? Clinical features...


Pernicious anaemia / Addisonian Pernicious Anaemia:

A vitamin B12 deficiency megaloblastic anaemia which occurs due to deficiency of intrinsic factor of Castle due to gastric atrophy, characterized by one or combination of macrocytic anaemia, glossitis and nervous system involvement.



Clinical features of pernicious anaemia:

1. Features of anaemia:
                a. Pallor
                b. Tiredness
                c. Palpitation     
                d. Effort angina

2. Paraesthesia

3. Glossitis

4. Recurrent diarrhea

5. Anorexia and weight loss

6. Abdominal pain

7. Mental disturbance

8. Visual disturbance

Note : In the making of the above article the follwing books were used:







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