Pathogenesis of pernicious anaemia:
Occurs due to gastric atrophy which in turn occurs due to genetic and autoimmune causes:
Causes of gastric atrophy:
1. Genetic causes:
a. Blood group A is more common.
b. In 10% patients more than one family member is affected.
c. occurs mostly in people of northern Europe and less frequently in oeple of southern Europe and asia.
d. Fair skin and blue eyes are common in patients with pernicious anaemia.
2. Autoimmune causes:
a. Anti-parietal cell antibodies: present in serum(85%) and gastric juice.
b. Anti-intrinsic factor antibodies: There are two types in the serum:
Note : In the making of the above article the follwing books were used: