How does aspirin prevent pain? Analgesic action of aspirin:
There are two mechanism by which aspirin combats pain:
1. Centrally aspirin acts at subcortical sites like thalamus and inhibits the pain stimuli, thus causing analgesia.
2. Peripherally it inhibtis the chemical mediators of acute inflammation (eg prostaglandin, leukotrienes, histamin, bradikinin) and prevent inflammation. So since there is no inflammation there is also no pain.
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