How does aspirin prevent inflammation? Anti-inflammatory action of aspirin
1. Prostaglandin is the main mediator of inflammation. Aspirin inhibits the synthesis of this prostaglandin by inhibiting the cycloxygenase (COX) enzyme. See the diagram below.
2. Other chemical mediators of inflammation such as the kalikrein system are also inhibited by aspirin. Thus aspirin inhibits:
· - Granulocyte adherence to damaged vasculature
· - Rupture of lysosome
· -Migration of polymorphonuclear leucocytes and macrophages to the site of inflammation
How much aspirin is needed to prevent inflammation?
High dose of aspirin ( more than 900mg) is required to prevent inflammation. It can be as high as 4000mg/day to treat conditions likes rheumatoid arthritis and osteoarthritis.
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